Ras and Cancer in the 21st Century

Ras and Cancer in the 21st Century
Author: Linda VanAelst
Publisher: Perspectives Cshl
Total Pages: 300
Release: 2018
Genre: Medical
ISBN: 9781621822219


Download Ras and Cancer in the 21st Century Book in PDF, Epub and Kindle

Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally active Ras proteins are common in human cancers, particularly those of the pancreas, lung, and colon. These cancers can be difficult to treat because Ras oncoproteins have long been considered 'undruggable.' Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids). The authors also discuss how organoids and mouse models are being used to study tumor progression and therapeutic efficacy. This volume is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with understanding and treating Ras-driven cancers.


Ras and Cancer in the 21st Century
Language: en
Pages: 300
Authors: Linda VanAelst
Categories: Medical
Type: BOOK - Published: 2018 - Publisher: Perspectives Cshl

GET EBOOK

Ras proteins are key molecular switches in cell signaling pathways that, when activated, trigger cell growth and division. Mutations that produce abnormally act
Waking and the Reticular Activating System in Health and Disease
Language: en
Pages: 330
Authors: Edgar Garcia-Rill
Categories: Medical
Type: BOOK - Published: 2015-04-28 - Publisher: Academic Press

GET EBOOK

Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating properties of the RAS. In health, the RA
The ras Superfamily of GTPases (1993)
Language: en
Pages: 719
Authors: Juan Carlos Lacal
Categories: Science
Type: BOOK - Published: 2017-11-22 - Publisher: CRC Press

GET EBOOK

The ras Superfamily of GTPases presents the most comprehensive compilation of information available regarding aspects of the putative function of small ras-rela
Inhibitors of the Ras Superfamily G-proteins, Part A
Language: en
Pages: 361
Authors:
Categories: Science
Type: BOOK - Published: 2013-08-08 - Publisher: Elsevier

GET EBOOK

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume di
Inhibitors of the Ras Superfamily G-proteins, Part B
Language: en
Pages: 275
Authors:
Categories: Science
Type: BOOK - Published: 2013-11-07 - Publisher: Academic Press

GET EBOOK

Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss