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This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.
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This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for
Papers of the May, 1988 meeting. They provide an overview of recent research and current theory in the field. Topics include the molecular biology and multiplic
Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. Th
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions a
Papers based on a symposium forming part of the Third Chemical Congress of No America held in Toronto, June, 1988 They deal with reactive chemicals formed the b
