Pegylated Protein Drugs Basic Science And Clinical Applications
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PEGylated Protein Drugs: Basic Science and Clinical Applications
Author | : Francesco M. Veronese |
Publisher | : Springer Science & Business Media |
Total Pages | : 289 |
Release | : 2009-12-30 |
Genre | : Medical |
ISBN | : 3764386797 |
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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
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