Novel Designs of Early Phase Trials for Cancer Therapeutics

Novel Designs of Early Phase Trials for Cancer Therapeutics
Author: Shivaani Kummar
Publisher: Academic Press
Total Pages: 234
Release: 2018-05-22
Genre: Medical
ISBN: 0128125705


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Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development


Novel Designs of Early Phase Trials for Cancer Therapeutics
Language: en
Pages: 234
Authors: Shivaani Kummar
Categories: Medical
Type: BOOK - Published: 2018-05-22 - Publisher: Academic Press

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Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the inte
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Language: en
Pages: 221
Authors: Institute of Medicine
Categories: Medical
Type: BOOK - Published: 2001-01-01 - Publisher: National Academies Press

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Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps
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Authors: Elizabeth A. Eisenhauer
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Type: BOOK - Published: 2015-03-20 - Publisher: Oxford University Press

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Phase I trials are a critical first step in the study of novel cancer therapeutic approaches. Their primary goals are to identify the recommended dose, schedule
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Authors: Timothy A. Yap
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This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicaliti
Oncology Clinical Trials
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Pages: 396
Authors: Susan Halabi, PhD
Categories: Medical
Type: BOOK - Published: 2009-12-22 - Publisher: Demos Medical Publishing

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Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well