Molecular Chaperones and Cell Signalling

Molecular Chaperones and Cell Signalling
Author: Brian Henderson
Publisher: Cambridge University Press
Total Pages: 366
Release: 2005-07-18
Genre: Science
ISBN: 1139444018


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This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?


Molecular Chaperones and Cell Signalling
Language: en
Pages: 366
Authors: Brian Henderson
Categories: Science
Type: BOOK - Published: 2005-07-18 - Publisher: Cambridge University Press

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This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecula
Molecular Chaperones in the Cell
Language: en
Pages: 308
Authors: Peter A. Lund
Categories: Science
Type: BOOK - Published: 2001 - Publisher: Oxford University Press, USA

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In this text, leading experts synthesise our body of knowledge , and the reader gains not only a fuller understanding of the roles of chaperones in the context
The Biology of Extracellular Molecular Chaperones
Language: en
Pages: 248
Authors: Derek J. Chadwick
Categories: Science
Type: BOOK - Published: 2008-04-30 - Publisher: John Wiley & Sons

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The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel prote
Molecular Chaperones in Health and Disease
Language: en
Pages: 444
Authors: Matthias Gaestel
Categories: Science
Type: BOOK - Published: 2005-12-29 - Publisher: Springer Science & Business Media

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Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially descri
Molecular Chaperones and Folding Catalysts
Language: en
Pages: 784
Authors: Bernd Bakau
Categories: Science
Type: BOOK - Published: 2003-09-02 - Publisher: CRC Press

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One of the most intriguing discoveries in molecular biology in the last decade is the existence of an evolutionary conserved and essential system, consisting of