Hic Pro An Optimized And Flexible Pipeline For Hi C Data Processing
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HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing
Author | : Oldenburg Oldenburg Press |
Publisher | : |
Total Pages | : 40 |
Release | : 2016-01-29 |
Genre | : |
ISBN | : 9781523764426 |
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HiC-Pro is an optimized and flexible pipeline for processing Hi-C data from raw reads to normalized contact maps. HiC-Pro maps reads, detects valid ligation products, performs quality controls and generates intra- and inter-chromosomal contact maps. It includes a fast implementation of the iterative correction method and is based on a memory-efficient data format for Hi-C contact maps. In addition, HiC-Pro can use phased genotype data to build allele-specific contact maps. We applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time. Source code and documentation are available at http://github.com/nservant/HiC-Pro.
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